PIM1 accelerates prostate cancer cell motility by phosphorylating actin capping proteins

Abstract Background The PIM family kinases promote cancer cell survival and motility as well as metastatic growth in various types of cancer. We have previously identified several PIM substrates, which support cancer cell migration and invasiveness. However, none of them are known to regulate cellul...

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Detalhes bibliográficos
Main Authors: Niina M. Santio, Veera Vainio, Tuuli Hoikkala, Kwan Long Mung, Mirka Lång, Riitta Vahakoski, Justyna Zdrojewska, Eleanor T. Coffey, Elena Kremneva, Eeva-Marja Rainio, Päivi J. Koskinen
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-08-01
Colecção:Cell Communication and Signaling
Assuntos:
PIM kinases
Capping proteins
CAPZ
Actin
Migration
Prostate cancer
Acesso em linha:http://link.springer.com/article/10.1186/s12964-020-00618-6
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