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Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development

Here we examined the involvement of Notch signaling in the endochondral ossification process, which is crucial for osteoarthritis (OA) development. Intracellular domains of Notch1 and -2 were translocated into the nucleus of chondrocytes with their differentiation in mouse limb cartilage and in mous...

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Autors principals: Hosaka, Yoko, Saito, Taku, Sugita, Shurei, Hikata, Tomohiro, Kobayashi, Hiroshi, Fukai, Atsushi, Taniguchi, Yuki, Hirata, Makoto, Akiyama, Haruhiko, Chung, Ung-il, Kawaguchi, Hiroshi
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562777/
https://ncbi.nlm.nih.gov/pubmed/23319657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207458110
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