Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes

In vitro studies have shown that Rela/p65, a key subunit mediating NF-κB signalling, is involved in chondrogenic differentiation, cell survival and catabolic enzyme production. Here, we analyse in vivo functions of Rela in embryonic limbs and adult articular cartilage, and find that Rela protects ch...

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Publicat a:Nat Commun
Autors principals: Kobayashi, Hiroshi, Chang, Song Ho, Mori, Daisuke, Itoh, Shozo, Hirata, Makoto, Hosaka, Yoko, Taniguchi, Yuki, Okada, Keita, Mori, Yoshifumi, Yano, Fumiko, Chung, Ung-il, Akiyama, Haruhiko, Kawaguchi, Hiroshi, Tanaka, Sakae, Saito, Taku
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5109547/
https://ncbi.nlm.nih.gov/pubmed/27830706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13336
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