Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes

In vitro studies have shown that Rela/p65, a key subunit mediating NF-κB signalling, is involved in chondrogenic differentiation, cell survival and catabolic enzyme production. Here, we analyse in vivo functions of Rela in embryonic limbs and adult articular cartilage, and find that Rela protects ch...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kobayashi, Hiroshi, Chang, Song Ho, Mori, Daisuke, Itoh, Shozo, Hirata, Makoto, Hosaka, Yoko, Taniguchi, Yuki, Okada, Keita, Mori, Yoshifumi, Yano, Fumiko, Chung, Ung-il, Akiyama, Haruhiko, Kawaguchi, Hiroshi, Tanaka, Sakae, Saito, Taku
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5109547/
https://ncbi.nlm.nih.gov/pubmed/27830706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13336
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