Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2

Notch signaling modulates skeletal formation and pathogenesis of osteoarthritis (OA) through induction of catabolic factors. Here we examined roles of Hes1, a transcription factor and important target of Notch signaling, in these processes. SRY-box containing gene 9 (Sox9)-Cre mice were mated with H...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sugita, Shurei, Hosaka, Yoko, Okada, Keita, Mori, Daisuke, Yano, Fumiko, Kobayashi, Hiroshi, Taniguchi, Yuki, Mori, Yoshifumi, Okuma, Tomotake, Chang, Song Ho, Kawata, Manabu, Taketomi, Shuji, Chikuda, Hirotaka, Akiyama, Haruhiko, Kageyama, Ryoichiro, Chung, Ung-il, Tanaka, Sakae, Kawaguchi, Hiroshi, Ohba, Shinsuke, Saito, Taku
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364241/
https://ncbi.nlm.nih.gov/pubmed/25733872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419699112
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