GSK-3α and GSK-3β Proteins Are Involved in Early Stages of Chondrocyte Differentiation with Functional Redundancy through RelA Protein Phosphorylation

Here we examine the roles of two isoforms of glycogen synthase kinase-3 (GSK-3), GSK-3α and GSK-3β, in skeletal development. Both isoforms were unphosphorylated and active in chondrocyte differentiation stages during SOX9 and type II collagen (COL2A1) expression. Although knock-out of both alleles o...

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Autors principals: Itoh, Shozo, Saito, Taku, Hirata, Makoto, Ushita, Masahiro, Ikeda, Toshiyuki, Woodgett, James R., Algül, Hana, Schmid, Roland M., Chung, Ung-il, Kawaguchi, Hiroshi
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436165/
https://ncbi.nlm.nih.gov/pubmed/22761446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.372086
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