Phosphorylation of GSK-3β by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes

cGMP-dependent protein kinase II (cGKII; encoded by PRKG2) is a serine/threonine kinase that is critical for skeletal growth in mammals; in mice, cGKII deficiency results in dwarfism. Using radiographic analysis, we determined that this growth defect was a consequence of an elongated growth plate an...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Kawasaki, Yosuke, Kugimiya, Fumitaka, Chikuda, Hirotaka, Kamekura, Satoru, Ikeda, Toshiyuki, Kawamura, Naohiro, Saito, Taku, Shinoda, Yusuke, Higashikawa, Akiro, Yano, Fumiko, Ogasawara, Toru, Ogata, Naoshi, Hoshi, Kazuto, Hofmann, Franz, Woodgett, James R., Nakamura, Kozo, Chung, Ung-il, Kawaguchi, Hiroshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2008
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423867/
https://ncbi.nlm.nih.gov/pubmed/18551195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35243
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge