Phosphorylation of GSK-3β by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes

cGMP-dependent protein kinase II (cGKII; encoded by PRKG2) is a serine/threonine kinase that is critical for skeletal growth in mammals; in mice, cGKII deficiency results in dwarfism. Using radiographic analysis, we determined that this growth defect was a consequence of an elongated growth plate an...

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Autors principals: Kawasaki, Yosuke, Kugimiya, Fumitaka, Chikuda, Hirotaka, Kamekura, Satoru, Ikeda, Toshiyuki, Kawamura, Naohiro, Saito, Taku, Shinoda, Yusuke, Higashikawa, Akiro, Yano, Fumiko, Ogasawara, Toru, Ogata, Naoshi, Hoshi, Kazuto, Hofmann, Franz, Woodgett, James R., Nakamura, Kozo, Chung, Ung-il, Kawaguchi, Hiroshi
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2008
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423867/
https://ncbi.nlm.nih.gov/pubmed/18551195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35243
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