Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension

The E3 ubiquitin ligase NEDD4-2 (encoded by the Nedd4L gene) regulates the amiloride-sensitive epithelial Na(+) channel (ENaC/SCNN1) to mediate Na(+) homeostasis. Mutations in the human β/γENaC subunits that block NEDD4-2 binding or constitutive ablation of exons 6–8 of Nedd4L in mice both result in...

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Detalhes bibliográficos
Main Authors: Ronzaud, Caroline, Loffing-Cueni, Dominique, Hausel, Pierrette, Debonneville, Anne, Malsure, Sumedha Ram, Fowler-Jaeger, Nicole, Boase, Natasha A., Perrier, Romain, Maillard, Marc, Yang, Baoli, Stokes, John B., Koesters, Robert, Kumar, Sharad, Hummler, Edith, Loffing, Johannes, Staub, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561795/
https://ncbi.nlm.nih.gov/pubmed/23348737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI61110
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