Lack of Renal Tubular Glucocorticoid Receptor Decreases the Thiazide-Sensitive Na(+)/Cl(–) Cotransporter NCC and Transiently Affects Sodium Handling

Chronic glucocorticoid infusion impairs NCC activity and induces a non-dipping profile in mice, suggesting that glucocorticoids are essential for daily blood pressure variations. In this paper, we studied mice lacking the renal tubular glucocorticoid receptor (GR) in adulthood (GR knockouts, Nr3c1(P...

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Pubblicato in:Front Physiol
Autori principali: Canonica, Jérémie, Frateschi, Simona, Boscardin, Emilie, Ebering, Anna, Sergi, Chloé, Jäger, Yannick, Peyrollaz, Thibaud, Mérillat, Anne-Marie, Maillard, Marc, Klusonova, Petra, Odermatt, Alex, Koesters, Robert, Debonneville, Anne, Staub, Olivier, Verouti, Sophia N., Hummler, Edith
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Physiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6702950/
https://ncbi.nlm.nih.gov/pubmed/31474871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.00989
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