Lack of Renal Tubular Glucocorticoid Receptor Decreases the Thiazide-Sensitive Na(+)/Cl(–) Cotransporter NCC and Transiently Affects Sodium Handling

Chronic glucocorticoid infusion impairs NCC activity and induces a non-dipping profile in mice, suggesting that glucocorticoids are essential for daily blood pressure variations. In this paper, we studied mice lacking the renal tubular glucocorticoid receptor (GR) in adulthood (GR knockouts, Nr3c1(P...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Canonica, Jérémie, Frateschi, Simona, Boscardin, Emilie, Ebering, Anna, Sergi, Chloé, Jäger, Yannick, Peyrollaz, Thibaud, Mérillat, Anne-Marie, Maillard, Marc, Klusonova, Petra, Odermatt, Alex, Koesters, Robert, Debonneville, Anne, Staub, Olivier, Verouti, Sophia N., Hummler, Edith
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6702950/
https://ncbi.nlm.nih.gov/pubmed/31474871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.00989
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