Mcl-1 and Bcl-xL Cooperatively Maintain Integrity of Hepatocytes in Developing and Adult Murine Liver

Anti-apoptotic members of the Bcl-2 family, including Bcl-2, Bcl-xL, Mcl-1, Bcl-w and Bfl-1, inhibit the mitochondrial pathway of apoptosis. Bcl-xL and Mcl-1 are constitutively expressed in the liver. Although previous research established Bcl-xL as a critical apoptosis antagonist in differentiated...

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Hauptverfasser: Hikita, Hayato, Takehara, Tetsuo, Shimizu, Satoshi, Kodama, Takahiro, Li, Wei, Miyagi, Takuya, Hosui, Atsushi, Ishida, Hisashi, Ohkawa, Kazuyoshi, Kanto, Tatsuya, Hiramatsu, Naoki, Yin, Xiao-Ming, Hennighausen, Lothar, Tatsumi, Tomohide, Hayashi, Norio
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3560852/
https://ncbi.nlm.nih.gov/pubmed/19676108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23126
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