Apixaban, an oral, direct factor Xa inhibitor: single dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects

AIMS: To evaluate apixaban single dose safety, tolerability, pharmacokinetics and pharmacodynamics and assess the effect of food on apixaban pharmacokinetics. METHODS: A double-blind, placebo-controlled, single ascending-dose, first-in-human study assessed apixaban safety, pharmacokinetics and pharm...

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Detalhes bibliográficos
Main Authors: Frost, Charles, Wang, Jessie, Nepal, Sunil, Schuster, Alan, Barrett, Yu Chen, Mosqueda-Garcia, Rogelio, Reeves, Richard A, LaCreta, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558798/
https://ncbi.nlm.nih.gov/pubmed/22759198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04369.x
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