Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs

Intervertebral disc degeneration (IDD) is the leading cause of debilitating spinal disorders such as chronic lower back pain. Aging is the greatest risk factor for IDD. Previously, we demonstrated IDD in a murine model of a progeroid syndrome caused by reduced expression of a key DNA repair enzyme....

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Hlavní autoři: Nasto, Luigi A., Wang, Dong, Robinson, Andria R., Clauson, Cheryl L., Ngo, Kevin, Dong, Qing, Roughley, Peter, Epperly, Michael, Huq, Saiful M., Pola, Enrico, Sowa, Gwendolyn, Robbins, Paul D., Kang, James, Niedernhofer, Laura J., Vo, Nam V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558562/
https://ncbi.nlm.nih.gov/pubmed/23262094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2012.11.002
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