ISSLS PRIZE WINNER: INHIBITION OF NF-κB ACTIVITY AMELIORATES AGE-ASSOCIATED DISC DEGENERATION IN A MOUSE MODEL OF ACCELERATED AGING

STUDY DESIGN: NF-κB activity was pharmacologically and genetically blocked in an accelerated aging mouse model to mitigate age-related disc degenerative changes. OBJECTIVE: To study the mediatory role of NF-κB signaling pathway in age-dependent intervertebral disc degeneration. SUMMARY OF BACKGROUND...

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Main Authors: Nasto, Luigi A., Seo, Hyoung-Yeon, Robinson, Andria R., Tilstra, Jeremy S., Clauson, Cheryl L., Sowa, Gwendolyn A., Ngo, Kevin, Dong, Qing, Pola, Enrico, Lee, Joon Y., Niedernhofer, Laura J., Kang, James D., Robbins, Paul D., Vo, Nam V.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395770/
https://ncbi.nlm.nih.gov/pubmed/22343279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/BRS.0b013e31824ee8f7
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