Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration

Oxidative damage is a well-established driver of aging. Evidence of oxidative stress exists in aged and degenerated discs, but it is unclear how it affects disc metabolism. In this study, we first determined whether oxidative stress negatively impacts disc matrix metabolism using disc organotypic an...

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Autors principals: Nasto, Luigi A., Robinson, Andria R., Ngo, Kevin, Clauson, Cheryl L., Dong, Qing, St. Croix, Claudette, Sowa, Gwendolyn, Pola, Enrico, Robbins, Paul D., Kang, James, Niedernhofer, Laura J., Wipf, Peter, Vo, Nam V.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668354/
https://ncbi.nlm.nih.gov/pubmed/23389888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jor.22320
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