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Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype

Aging greatly increases the risk for intervertebral disc degeneration (IDD) as a result of proteoglycan loss due to reduced synthesis and enhanced degradation of the disc matrix proteoglycan (PG). How disc matrix PG homeostasis becomes perturbed with age is not known. The goal of this study is to de...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mech Ageing Dev
Main Authors: Ngo, Kevin, Patil, Prashanti, McGowan, Sara J., Niedernhofer, Laura J., Robbins, Paul D., Kang, James, Sowa, Gwendolyn, Vo, Nam
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5632945/
https://ncbi.nlm.nih.gov/pubmed/28830687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2017.08.007
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