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Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator
Inhibitors of Apoptosis Proteins (IAPs) are guardian ubiquitin ligases that keep classic pro-apoptotic proteins in check. Systematic identification of additional IAP substrates is challenged by the heterogeneity and sheer number of ubiquitinated proteins (>5000). Here we report a powerful catalyt...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3557559/ https://ncbi.nlm.nih.gov/pubmed/23201124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.10.022 |
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