Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes

Protein ubiquitination is mediated sequentially by ubiquitin activating enzyme E1, ubiquitin conjugating enzyme E2 and ubiquitin ligase E3. Uba1 was thought to be the only E1 until the recent identification of Uba6. To differentiate the biological functions of Uba1 and Uba6, we applied an orthogonal...

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Udgivet i:Nat Commun
Main Authors: Liu, Xianpeng, Zhao, Bo, Sun, Limin, Bhuripanyo, Karan, Wang, Yiyang, Bi, Yingtao, Davuluri, Ramana V., Duong, Duc M., Nanavati, Dhaval, Yin, Jun, Kiyokawa, Hiroaki
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290280/
https://ncbi.nlm.nih.gov/pubmed/28134249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14286
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