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Orthogonal Ubiquitin Transfer through Engineered E1-E2 Cascades for Protein Ubiquitination
Protein modification by ubiquitin (UB) controls diverse cellular processes. UB is conjugated to cellular proteins by sequential transfer through an E1-E2-E3 enzymatic cascade. The cross-activities of 2 E1s, 50 E2s and thousands of E3s encoded by the human genome make it difficult to identify the sub...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4104569/ https://ncbi.nlm.nih.gov/pubmed/23102221 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.07.023 |
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