Orthogonal Ubiquitin Transfer through Engineered E1-E2 Cascades for Protein Ubiquitination

Protein modification by ubiquitin (UB) controls diverse cellular processes. UB is conjugated to cellular proteins by sequential transfer through an E1-E2-E3 enzymatic cascade. The cross-activities of 2 E1s, 50 E2s and thousands of E3s encoded by the human genome make it difficult to identify the sub...

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Bibliographic Details
Main Authors: Zhao, Bo, Bhuripanyo, Karan, Zhang, Keya, Kiyokawa, Hiroaki, Schindelin, Hermann, Yin, Jun
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104569/
https://ncbi.nlm.nih.gov/pubmed/23102221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.07.023
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