HIV relies on neddylation for ubiquitin ligase-mediated functions

BACKGROUND: HIV and SIV defeat antiviral proteins by usurping Cullin-RING E3 ubiquitin ligases (CRLs) and likely influence other cellular processes through these as well. HIV-2 viral protein X (Vpx) engages the cullin4-containing CRL4 complex to deplete the antiviral protein SAMHD1. Vif expressed by...

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Main Authors: Nekorchuk, Michael D, Sharifi, Hamayun J, Furuya, Andrea KM, Jellinger, Robert, de Noronha, Carlos MC
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2013
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842660/
https://ncbi.nlm.nih.gov/pubmed/24245672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-138
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