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Escherichia coli DNA polymerase III is responsible for the high level of spontaneous mutations in mutT strains

Reactive oxygen species induce oxidative damage in DNA precursors, i.e. dNTPs, leading to point mutations upon incorporation. Escherichia coli mutT strains, deficient in the activity hydrolysing 8-oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphate (8-oxo-dGTP), display more than a 100-fold higher spo...

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Bibliografski detalji
Glavni autori: Yamada, Masami, Shimizu, Masatomi, Katafuchi, Atsushi, Grúz, Petr, Fujii, Shingo, Usui, Yukio, Fuchs, Robert P, Nohmi, Takehiko
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Publishing Ltd 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3556519/
https://ncbi.nlm.nih.gov/pubmed/23043439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.12061
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