Escherichia coli DNA polymerase III is responsible for the high level of spontaneous mutations in mutT strains

Reactive oxygen species induce oxidative damage in DNA precursors, i.e. dNTPs, leading to point mutations upon incorporation. Escherichia coli mutT strains, deficient in the activity hydrolysing 8-oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphate (8-oxo-dGTP), display more than a 100-fold higher spo...

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Detaylı Bibliyografya
Asıl Yazarlar: Yamada, Masami, Shimizu, Masatomi, Katafuchi, Atsushi, Grúz, Petr, Fujii, Shingo, Usui, Yukio, Fuchs, Robert P, Nohmi, Takehiko
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Publishing Ltd 2012
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3556519/
https://ncbi.nlm.nih.gov/pubmed/23043439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.12061
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