Escherichia coli DNA polymerase III is responsible for the high level of spontaneous mutations in mutT strains

Reactive oxygen species induce oxidative damage in DNA precursors, i.e. dNTPs, leading to point mutations upon incorporation. Escherichia coli mutT strains, deficient in the activity hydrolysing 8-oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphate (8-oxo-dGTP), display more than a 100-fold higher spo...

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Autores principales: Yamada, Masami, Shimizu, Masatomi, Katafuchi, Atsushi, Grúz, Petr, Fujii, Shingo, Usui, Yukio, Fuchs, Robert P, Nohmi, Takehiko
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2012
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3556519/
https://ncbi.nlm.nih.gov/pubmed/23043439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.12061
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