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Critical amino acids in human DNA polymerases η and κ involved in erroneous incorporation of oxidized nucleotides
Oxidized DNA precursors can cause mutagenesis and carcinogenesis when they are incorporated into the genome. Some human Y-family DNA polymerases (Pols) can effectively incorporate 8-oxo-dGTP, an oxidized form of dGTP, into a position opposite a template dA. This inappropriate G:A pairing may lead to...
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| Main Authors: | , , , , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Oxford University Press
2010
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2817480/ https://ncbi.nlm.nih.gov/pubmed/19939936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1095 |
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