Critical amino acids in human DNA polymerases η and κ involved in erroneous incorporation of oxidized nucleotides

Oxidized DNA precursors can cause mutagenesis and carcinogenesis when they are incorporated into the genome. Some human Y-family DNA polymerases (Pols) can effectively incorporate 8-oxo-dGTP, an oxidized form of dGTP, into a position opposite a template dA. This inappropriate G:A pairing may lead to...

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Détails bibliographiques
Auteurs principaux: Katafuchi, Atsushi, Sassa, Akira, Niimi, Naoko, Grúz, Petr, Fujimoto, Hirofumi, Masutani, Chikahide, Hanaoka, Fumio, Ohta, Toshihiro, Nohmi, Takehiko
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2010
Sujets:
Genome Integrity, Repair and Replication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817480/
https://ncbi.nlm.nih.gov/pubmed/19939936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1095
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