Erroneous incorporation of oxidized DNA precursors by Y-family DNA polymerases

Deranged oxidative metabolism is a property of many tumour cells. Oxidation of the deoxynucleotide triphosphate (dNTP) pool, as well as DNA, is a major cause of genome instability. Here, we report that two Y-family DNA polymerases of the archaeon Sulfolobus solfataricus strains P1 and P2 incorporate...

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Hauptverfasser: Shimizu, Masatomi, Gruz, Petr, Kamiya, Hiroyuki, Kim, Su-Ryang, Pisani, Francesca M., Masutani, Chikahide, Kanke, Yusuke, Harashima, Hideyoshi, Hanaoka, Fumio, Nohmi, Takehiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2003
Schlagworte:
Scientific Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1315893/
https://ncbi.nlm.nih.gov/pubmed/12634844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.embor765
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