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Erroneous incorporation of oxidized DNA precursors by Y-family DNA polymerases
Deranged oxidative metabolism is a property of many tumour cells. Oxidation of the deoxynucleotide triphosphate (dNTP) pool, as well as DNA, is a major cause of genome instability. Here, we report that two Y-family DNA polymerases of the archaeon Sulfolobus solfataricus strains P1 and P2 incorporate...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1315893/ https://ncbi.nlm.nih.gov/pubmed/12634844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.embor765 |
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