Translesional DNA Synthesis through a C8-Guanyl Adduct of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Vitro: REV1 INSERTS dC OPPOSITE THE LESION, AND DNA POLYMERASE κ POTENTIALLY CATALYZES EXTENSION REACTION FROM THE 3′-dC TERMINUS

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundant heterocyclic amine in cooked foods, and is both mutagenic and carcinogenic. It has been suspected that the carcinogenicity of PhIP is derived from its ability to form DNA adducts, principally dG-C8-PhIP. To shed further ligh...

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Detalhes bibliográficos
Main Authors: Fukuda, Hirokazu, Takamura-Enya, Takeji, Masuda, Yuji, Nohmi, Takehiko, Seki, Chiho, Kamiya, Kenji, Sugimura, Takashi, Masutani, Chikahide, Hanaoka, Fumio, Nakagama, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757960/
https://ncbi.nlm.nih.gov/pubmed/19628463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.037259
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