Translesional DNA Synthesis through a C8-Guanyl Adduct of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Vitro: REV1 INSERTS dC OPPOSITE THE LESION, AND DNA POLYMERASE κ POTENTIALLY CATALYZES EXTENSION REACTION FROM THE 3′-dC TERMINUS

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundant heterocyclic amine in cooked foods, and is both mutagenic and carcinogenic. It has been suspected that the carcinogenicity of PhIP is derived from its ability to form DNA adducts, principally dG-C8-PhIP. To shed further ligh...

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Bibliografiska uppgifter
Huvudupphovsmän: Fukuda, Hirokazu, Takamura-Enya, Takeji, Masuda, Yuji, Nohmi, Takehiko, Seki, Chiho, Kamiya, Kenji, Sugimura, Takashi, Masutani, Chikahide, Hanaoka, Fumio, Nakagama, Hitoshi
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2009
Ämnen:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757960/
https://ncbi.nlm.nih.gov/pubmed/19628463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.037259
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