Translesional DNA Synthesis through a C8-Guanyl Adduct of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Vitro: REV1 INSERTS dC OPPOSITE THE LESION, AND DNA POLYMERASE κ POTENTIALLY CATALYZES EXTENSION REACTION FROM THE 3′-dC TERMINUS

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundant heterocyclic amine in cooked foods, and is both mutagenic and carcinogenic. It has been suspected that the carcinogenicity of PhIP is derived from its ability to form DNA adducts, principally dG-C8-PhIP. To shed further ligh...

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Dettagli Bibliografici
Autori principali: Fukuda, Hirokazu, Takamura-Enya, Takeji, Masuda, Yuji, Nohmi, Takehiko, Seki, Chiho, Kamiya, Kenji, Sugimura, Takashi, Masutani, Chikahide, Hanaoka, Fumio, Nakagama, Hitoshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
Soggetti:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757960/
https://ncbi.nlm.nih.gov/pubmed/19628463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.037259
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