Escherichia coli DNA polymerase III is responsible for the high level of spontaneous mutations in mutT strains

Reactive oxygen species induce oxidative damage in DNA precursors, i.e. dNTPs, leading to point mutations upon incorporation. Escherichia coli mutT strains, deficient in the activity hydrolysing 8-oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphate (8-oxo-dGTP), display more than a 100-fold higher spo...

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Hlavní autoři: Yamada, Masami, Shimizu, Masatomi, Katafuchi, Atsushi, Grúz, Petr, Fujii, Shingo, Usui, Yukio, Fuchs, Robert P, Nohmi, Takehiko
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2012
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3556519/
https://ncbi.nlm.nih.gov/pubmed/23043439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.12061
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