Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX(3)CR1)-deficient mice

An impaired ability to regulate the activation of microglia by fractalkine (CX(3)CL1) leads to persistent neuroinflammation and behavioral alterations following lipopolysaccharide (LPS) challenge. While these responses are usually transient, LPS injection caused prolonged depressive-like behavior in...

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Hlavní autoři: Corona, Angela W., Norden, Diana M., Skendelas, John P., Huang, Yan, O’Connor, Jason C., Lawson, Marcus, Dantzer, Robert, Kelley, Keith W., Godbout, Jonathan P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554840/
https://ncbi.nlm.nih.gov/pubmed/22926082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2012.08.008
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