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Primary Murine Microglia are Resistant to Nitric Oxide Inhibition of Indoleamine 2, 3 Dioxygenase
Indoleamine 2,3-dioxygenase (IDO) is an intracellular heme containing enzyme that is activated by proinflammatory cytokines, including interferon-γ (IFNγ), and metabolizes tryptophan along the kynurenine pathway. Activation of murine macrophages induces not only IDO but also nitric oxide synthase (i...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2948631/ https://ncbi.nlm.nih.gov/pubmed/20451602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2010.04.015 |
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