Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2,3-dioxygenase-dependent depression-like behaviors

BACKGROUND: Activation of the tryptophan degrading enzyme indoleamine-2,3-dioxygenase 1 (IDO1) is associated with the development of behavioral signs of depression. Systemic immune challenge induces IDO1 in both the periphery and the brain, leading to increased circulating and brain concentrations o...

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Detalhes bibliográficos
Main Authors: Lawson, Marcus A, Parrott, Jennifer M, McCusker, Robert H, Dantzer, Robert, Kelley, Keith W, O’Connor, Jason C
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733827/
https://ncbi.nlm.nih.gov/pubmed/23866724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-10-87
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