Central Administration of Lipopolysaccharide Induces Depressive-like Behavior in Vivo and Activates Brain Indoleamine 2,3 Dioxygenase In Murine Organotypic Hippocampal Slice Cultures

BACKGROUND: Transient stimulation of the innate immune system by an intraperitoneal injection of lipopolysaccharide (LPS) activates peripheral and central expression of the tryptophan degrading enzyme indoleamine 2,3 dioxygenase (IDO) which mediates depressive-like behavior. It is unknown whether di...

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Detalhes bibliográficos
Main Authors: Fu, Xin, Zunich, Samantha M, O'Connor, Jason C, Kavelaars, Annemieke, Dantzer, Robert, Kelley, Keith W
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921406/
https://ncbi.nlm.nih.gov/pubmed/20678226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-7-43
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