Alkyl-Substituted Polyaminohydroxamic Acids: A Novel Class of Targeted Histone Deacetylase Inhibitors

The reversible acetylation of histones is critical for regulation of eukaryotic gene expression. The histone deacetylase inhibitors trichostatin (TSA, 1), MS-275 (2) and suberoylanilide hydroxamic acid (SAHA, 3) arrest growth in transformed cells and in human tumor xenografts. However, 1–3 suffer fr...

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Hlavní autoři: Varghese, Sheeba, Gupta, Deepak, Baran, Tiffany, Jiemjit, Anchalee, Gore, Steven D., Casero, Robert A., Woster, Patrick M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554812/
https://ncbi.nlm.nih.gov/pubmed/16190761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0505009
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