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Polyaminohydroxamic Acids and Polyaminobenzamides as Isoform Selective Histone Deacetylase Inhibitors

A series of polyaminohydroxamic acids (PAHAs) and polyaminobenzamides (PABAs) were synthesized and evaluated as isoform-selective histone deacetylase (HDAC) inhibitors. These analogues contain a polyamine chain to increase affinity for chromatin and facilitate cellular import. Seven PAHAs inhibited...

詳細記述

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書誌詳細
主要な著者: Varghese, Sheeba, Senanayake, Thulani, Murray-Stewart, Tracey, Doering, Kim, Fraser, Alison, Casero, Robert A., Woster, Patrick M.
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3556737/
https://ncbi.nlm.nih.gov/pubmed/18348516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm701384x
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