Discovery of the first-in-class dual histone deacetylase-proteasome inhibitor

Dual- or multi-target drugs have emerged as a promising alternative to combination therapies. Proteasome inhibitors (PIs) possess synergistic activity with histone deacetylase (HDAC) inhibitors due to the simultaneous blockage of the ubiquitin-degradation and aggresome pathways. Here, we present the...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:J Med Chem
Main Authors: Bhatia, Sanil, Krieger, Viktoria, Groll, Michael, Osko, Jeremy D., Reßing, Nina, Ahlert, Heinz, Borkhardt, Arndt, Kurz, Thomas, Christianson, David W., Hauer, Julia, Hansen, Finn K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2018
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249066/
https://ncbi.nlm.nih.gov/pubmed/30365892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01487
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla