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Discovery of a new class of histone deacetylase inhibitors with a novel zinc binding group
Small molecules featuring a hydroxamic acid or a benzamide zinc binding group (ZBG) are the most thoroughly studied histone deacetylase (HDAC) inhibitors. However, concerns about the pharmacokinetic liabilities of the hydroxamic acid moiety and potential metabolic toxicity of the aniline portion of...
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| Publicado no: | Medchemcomm |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4440699/ https://ncbi.nlm.nih.gov/pubmed/26005563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C4MD00401A |
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