Hepatitis C Virus Variants with Decreased Sensitivity to Direct-Acting Antivirals (DAAs) Were Rarely Observed in DAA-Naive Patients prior to Treatment

The prevalence of naturally occurring hepatitis C virus (HCV) variants that are less sensitive to direct-acting antiviral (DAA) inhibitors has not been fully characterized. We used population sequence analysis to assess the frequency of such variants in plasma samples from 3,447 DAA-naive patients w...

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Autors principals: Bartels, Doug J., Sullivan, James C., Zhang, Eileen Z., Tigges, Ann M., Dorrian, Jennifer L., De Meyer, Sandra, Takemoto, Darin, Dondero, Elizabeth, Kwong, Ann D., Picchio, Gaston, Kieffer, Tara L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2013
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554180/
https://ncbi.nlm.nih.gov/pubmed/23152524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02294-12
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