Genotypic and Phenotypic Analyses of Hepatitis C Virus Variants Observed in Clinical Studies of VX-222, a Nonnucleoside NS5B Polymerase Inhibitor

VX-222, a thiophene-2-carboxylic acid derivative, is a selective nonnucleoside inhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. In phase 1 and 2 clinical studies, VX-222 demonstrated effective antiviral efficacy, with substantial reductions in plasma HCV RNA in patients ch...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Jiang, Min, Zhang, Eileen Z., Ardzinski, Andrzej, Tigges, Ann, Davis, Andrew, Sullivan, James C., Nelson, Michelle, Spanks, Joan, Dorrian, Jennifer, Nicolas, Olivier, Bartels, Doug J., Rao, B. Govinda, Rijnbrand, Rene, Kieffer, Tara L.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2014
Sujets:
Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135882/
https://ncbi.nlm.nih.gov/pubmed/24982088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03052-14
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