Genotypic and Phenotypic Analyses of Hepatitis C Virus Variants Observed in Clinical Studies of VX-222, a Nonnucleoside NS5B Polymerase Inhibitor

VX-222, a thiophene-2-carboxylic acid derivative, is a selective nonnucleoside inhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. In phase 1 and 2 clinical studies, VX-222 demonstrated effective antiviral efficacy, with substantial reductions in plasma HCV RNA in patients ch...

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Библиографические подробности
Главные авторы: Jiang, Min, Zhang, Eileen Z., Ardzinski, Andrzej, Tigges, Ann, Davis, Andrew, Sullivan, James C., Nelson, Michelle, Spanks, Joan, Dorrian, Jennifer, Nicolas, Olivier, Bartels, Doug J., Rao, B. Govinda, Rijnbrand, Rene, Kieffer, Tara L.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2014
Предметы:
Antiviral Agents
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135882/
https://ncbi.nlm.nih.gov/pubmed/24982088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03052-14
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