The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets

Animal miRNAs silence the expression of mRNA targets through translational repression, deadenylation and subsequent mRNA degradation. Silencing requires association of miRNAs with an Argonaute protein and a GW182 family protein. In turn, GW182 proteins interact with poly(A)-binding protein (PABP) an...

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Hlavní autoři: Huntzinger, Eric, Kuzuoğlu-Öztürk, Duygu, Braun, Joerg E., Eulalio, Ana, Wohlbold, Lara, Izaurralde, Elisa
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Molecular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553986/
https://ncbi.nlm.nih.gov/pubmed/23172285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1078
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