The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets

Animal miRNAs silence the expression of mRNA targets through translational repression, deadenylation and subsequent mRNA degradation. Silencing requires association of miRNAs with an Argonaute protein and a GW182 family protein. In turn, GW182 proteins interact with poly(A)-binding protein (PABP) an...

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Bibliographic Details
Main Authors: Huntzinger, Eric, Kuzuoğlu-Öztürk, Duygu, Braun, Joerg E., Eulalio, Ana, Wohlbold, Lara, Izaurralde, Elisa
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553986/
https://ncbi.nlm.nih.gov/pubmed/23172285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1078
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