Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing

miRNA-mediated gene silencing requires the GW182 proteins, which are characterized by an N-terminal domain that interacts with Argonaute proteins (AGOs), and a C-terminal silencing domain (SD). In Drosophila melanogaster (Dm) GW182 and a human (Hs) orthologue, TNRC6C, the SD was previously shown to...

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Hauptverfasser: Huntzinger, Eric, Braun, Joerg E, Heimstädt, Susanne, Zekri, Latifa, Izaurralde, Elisa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018788/
https://ncbi.nlm.nih.gov/pubmed/21063388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.274
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