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Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing
miRNA-mediated gene silencing requires the GW182 proteins, which are characterized by an N-terminal domain that interacts with Argonaute proteins (AGOs), and a C-terminal silencing domain (SD). In Drosophila melanogaster (Dm) GW182 and a human (Hs) orthologue, TNRC6C, the SD was previously shown to...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3018788/ https://ncbi.nlm.nih.gov/pubmed/21063388 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.274 |
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