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A C-terminal silencing domain in GW182 is essential for miRNA function

Proteins of the GW182 family are essential for miRNA-mediated gene silencing in animal cells; they interact with Argonaute proteins (AGOs) and are required for both the translational repression and mRNA degradation mediated by miRNAs. To gain insight into the role of the GW182–AGO1 interaction in si...

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Sonraí Bibleagrafaíochta
Main Authors: Eulalio, Ana, Helms, Sigrun, Fritzsch, Christoph, Fauser, Maria, Izaurralde, Elisa
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cold Spring Harbor Laboratory Press 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685512/
https://ncbi.nlm.nih.gov/pubmed/19383769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1605509
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