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A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing

In eukaryotic cells degradation of bulk mRNA in the 5′ to 3′ direction requires the consecutive action of the decapping complex (consisting of DCP1 and DCP2) and the 5′ to 3′ exonuclease XRN1. These enzymes are found in discrete cytoplasmic foci known as P-bodies or GW-bodies (because of the accumul...

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Detalhes bibliográficos
Main Authors: REHWINKEL, JAN, BEHM-ANSMANT, ISABELLE, GATFIELD, DAVID, IZAURRALDE, ELISA
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright 2005 by RNA Society 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370850/
https://ncbi.nlm.nih.gov/pubmed/16177138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2191905
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