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GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation

GW182 family proteins interact with Argonaute proteins and are required for the translational repression, deadenylation and decay of miRNA targets. To elicit these effects, GW182 proteins interact with poly(A)-binding protein (PABP) and the CCR4–NOT deadenylase complex. Although the mechanism of miR...

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Bibliographic Details
Main Authors: Zekri, Latifa, Kuzuoğlu-Öztürk, Duygu, Izaurralde, Elisa
Format: Artigo
Language:Inglês
Published: European Molecular Biology Organization 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616289/
https://ncbi.nlm.nih.gov/pubmed/23463101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.44
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