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GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation

GW182 family proteins interact with Argonaute proteins and are required for the translational repression, deadenylation and decay of miRNA targets. To elicit these effects, GW182 proteins interact with poly(A)-binding protein (PABP) and the CCR4–NOT deadenylase complex. Although the mechanism of miR...

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書誌詳細
主要な著者: Zekri, Latifa, Kuzuoğlu-Öztürk, Duygu, Izaurralde, Elisa
フォーマット: Artigo
言語:Inglês
出版事項: European Molecular Biology Organization 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616289/
https://ncbi.nlm.nih.gov/pubmed/23463101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.44
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