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GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation

GW182 family proteins interact with Argonaute proteins and are required for the translational repression, deadenylation and decay of miRNA targets. To elicit these effects, GW182 proteins interact with poly(A)-binding protein (PABP) and the CCR4–NOT deadenylase complex. Although the mechanism of miR...

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Bibliografski detalji
Glavni autori: Zekri, Latifa, Kuzuoğlu-Öztürk, Duygu, Izaurralde, Elisa
Format: Artigo
Jezik:Inglês
Izdano: European Molecular Biology Organization 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616289/
https://ncbi.nlm.nih.gov/pubmed/23463101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.44
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