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GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation
GW182 family proteins interact with Argonaute proteins and are required for the translational repression, deadenylation and decay of miRNA targets. To elicit these effects, GW182 proteins interact with poly(A)-binding protein (PABP) and the CCR4–NOT deadenylase complex. Although the mechanism of miR...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
European Molecular Biology Organization
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3616289/ https://ncbi.nlm.nih.gov/pubmed/23463101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.44 |
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