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GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation
GW182 family proteins interact with Argonaute proteins and are required for the translational repression, deadenylation and decay of miRNA targets. To elicit these effects, GW182 proteins interact with poly(A)-binding protein (PABP) and the CCR4–NOT deadenylase complex. Although the mechanism of miR...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
European Molecular Biology Organization
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3616289/ https://ncbi.nlm.nih.gov/pubmed/23463101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.44 |
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