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The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets
Animal miRNAs silence the expression of mRNA targets through translational repression, deadenylation and subsequent mRNA degradation. Silencing requires association of miRNAs with an Argonaute protein and a GW182 family protein. In turn, GW182 proteins interact with poly(A)-binding protein (PABP) an...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3553986/ https://ncbi.nlm.nih.gov/pubmed/23172285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1078 |
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