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Crystal structure of a voltage-gated sodium channel in two potentially inactivated states
In excitable cells, voltage-gated sodium (Na(V)) channels activate to initiate action potentials and then undergo fast and slow inactivation processes that terminate their ionic conductance(1,2). Inactivation is a hallmark of Na(V) channel function and is critical for control of membrane excitabilit...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3552482/ https://ncbi.nlm.nih.gov/pubmed/22678296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11077 |
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