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Crystal structure of a voltage-gated sodium channel in two potentially inactivated states

In excitable cells, voltage-gated sodium (Na(V)) channels activate to initiate action potentials and then undergo fast and slow inactivation processes that terminate their ionic conductance(1,2). Inactivation is a hallmark of Na(V) channel function and is critical for control of membrane excitabilit...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Payandeh, Jian, Gamal El-Din, Tamer M., Scheuer, Todd, Zheng, Ning, Catterall, William A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552482/
https://ncbi.nlm.nih.gov/pubmed/22678296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11077
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