Combined Modifications of Mexiletine Pharmacophores for New Lead Blockers of Na(v)1.4 Channels

Previously identified potent and/or use-dependent mexiletine (Mex) analogs were used as template for the rational design of new Na(v)-channel blockers. The effects of the novel analogs were tested on sodium currents of native myofibers. Data and molecular modeling show that increasing basicity and o...

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Autors principals: De Bellis, Michela, De Luca, Annamaria, Desaphy, Jean F., Carbonara, Roberta, Heiny, Judith A., Kennedy, Ann, Carocci, Alessia, Cavalluzzi, Maria M., Lentini, Giovanni, Franchini, Carlo, Conte Camerino, Diana
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2013
Matèries:
Channels and Transporters
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552273/
https://ncbi.nlm.nih.gov/pubmed/23442856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.11.3830
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