The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain

Regulated intramembrane proteolysis is a central cellular process involved in signal transduction and membrane protein turnover. The presenilin homologue signal-peptide-peptidase-like 2a (SPPL2a) has been implicated in the cleavage of type 2 transmembrane proteins. We show that the invariant chain (...

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Bibliografiske detaljer
Main Authors: Schneppenheim, Janna, Dressel, Ralf, Hüttl, Susann, Lüllmann-Rauch, Renate, Engelke, Michael, Dittmann, Kai, Wienands, Jürgen, Eskelinen, Eeva-Liisa, Hermans-Borgmeyer, Irm, Fluhrer, Regina, Saftig, Paul, Schröder, Bernd
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549707/
https://ncbi.nlm.nih.gov/pubmed/23267015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121069
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