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The Intramembrane Proteases Signal Peptide Peptidase-Like 2a and 2b Have Distinct Functions In Vivo
We reported recently that the presenilin homologue signal peptide peptidase-like 2a (SPPL2a) is essential for B cell development by cleaving the N-terminal fragment (NTF) of the invariant chain (li, CD74). Based on this, we suggested that pharmacological modulation of SPPL2a may represent a novel ap...
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Главные авторы: | , , , , , , , , , , , , , |
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Формат: | Artigo |
Язык: | Inglês |
Опубликовано: |
American Society for Microbiology
2014
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Предметы: | |
Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3993588/ https://ncbi.nlm.nih.gov/pubmed/24492962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00038-14 |
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