Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells

The invariant chain (CD74) mediates targeting of the MHCII complex to endosomal compartments, where CD74 undergoes degradation allowing MHCII to acquire peptides. We demonstrated recently that intramembrane proteolysis of the final membrane-bound N-terminal fragment (NTF) of CD74 is catalysed by Sig...

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Bibliografski detalji
Izdano u:Biochem Biophys Res Commun
Glavni autori: Schneppenheim, Janna, Hüttl, Susann, Kruchen, Anne, Fluhrer, Regina, Müller, Ingo, Saftig, Paul, Schneppenheim, Reinhard, Martin, Christa L, Schröder, Bernd
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476656/
https://ncbi.nlm.nih.gov/pubmed/25035924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2014.07.051
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