Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells

The invariant chain (CD74) mediates targeting of the MHCII complex to endosomal compartments, where CD74 undergoes degradation allowing MHCII to acquire peptides. We demonstrated recently that intramembrane proteolysis of the final membrane-bound N-terminal fragment (NTF) of CD74 is catalysed by Sig...

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Bibliographic Details
Published in:Biochem Biophys Res Commun
Main Authors: Schneppenheim, Janna, Hüttl, Susann, Kruchen, Anne, Fluhrer, Regina, Müller, Ingo, Saftig, Paul, Schneppenheim, Reinhard, Martin, Christa L, Schröder, Bernd
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476656/
https://ncbi.nlm.nih.gov/pubmed/25035924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2014.07.051
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