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Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells
The invariant chain (CD74) mediates targeting of the MHCII complex to endosomal compartments, where CD74 undergoes degradation allowing MHCII to acquire peptides. We demonstrated recently that intramembrane proteolysis of the final membrane-bound N-terminal fragment (NTF) of CD74 is catalysed by Sig...
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| Published in: | Biochem Biophys Res Commun |
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| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4476656/ https://ncbi.nlm.nih.gov/pubmed/25035924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2014.07.051 |
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